Glutamate, ALS, and Cell Death

To understand the basis for the Neuro-Health Protocol, one must first consider the pathology in neurodegenerative conditions in general and ALS specifically. One theory says that death of motor neurons spreads throughout the body in individuals with ALS due to glutamate. When cells die, they burst and release intracellular glutamate into the extracellular space. This increase in extracellular glutamate causes neighboring healthy motor neurons to die, to burst, and to release more glutamate into extracellular space, which will kill even more neighboring cells. This so-called storm of glutamate in ALS causes cell death to happen at an exponential rate. (The spread of cell death via excess extracellular glutamate has already been proven in other neurodegenerative conditions, such as traumatic brain injury. It has not yet been proven in ALS research. However, we know that all cells release glutamate when they die and that excess extracellular glutamate kills neighboring cells, regardless of the disease/condition.)

The same theory, hypothesizes that somehow, the exposure to excess extracellular glutamate in ALS kills neighboring healthy neurons by interrupting the Krebs Cycle in each of them. The Krebs Cycle interruption is possibly a chief cause of cell death. After all, when cells cannot produce energy efficiently, they die.

How the Neuro-Health Protocol by Simplesa® May Help Stop Cell Death Caused by Extracellular Glutamate in ALS

Does the Neuro-Health Protocol neutralize the excess extracellular glutamate in ALS? No. The Neuro-Health Protocol focuses on cell metabolism. The Neuro-Health Protocol delivers Alpha-ketoglutarate (AKG) to the Krebs Cycle in the neurons. The increase in AKG enables their mitochondria to produce enough energy to help keep cells alive, despite their exposure to an unhealthy amount of extracellular glutamate.*

*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.