Suggested by Winning the Fight, Simplesa products are specifically formulated for the Deanna Protocol® Program for ALS.

The Deanna Protocol® is a part of the Winning the Fight Program for ALS, an all-natural metabolic program developed by Dr. Vincent Tedone through his research on Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease). Scientific studies conducted on the Deanna Protocol® by Winning the Fight have shown promising results. To view research studies, CLICK HERE.
Simplesa multi-pack bundles combine the nutrients in various forms (AKG Liquid or Capsules) for easy ordering. All multi-pack bundles provide a 30-day supply. We provide complete instructions, videos, and a personalized call upon delivery.
Why the Deanna Protocol® Works
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The below content was taken and repurposed from the Winning the Fight website. You can find the original HERE.
Glutamate, ALS, and Cell Death
To understand the basis for the Deanna Protocol® Metabolic Plan, one must first consider the pathology in neurodegenerative conditions in general and ALS specifically. Death of motor neurons spreads throughout the body in individuals with ALS due to glutamate. When cells die, they burst and release intracellular glutamate into the extracellular space. This increase in extracellular glutamate causes neighboring healthy motor neurons to die, to burst, and to release more glutamate into extracellular space, which will kill even more neighboring cells. This so-called storm of glutamate in ALS causes cell death to happen at an exponential rate. (The spread of cell death via excess extracellular glutamate has already been proven in other neurodegenerative conditions, such as traumatic brain injury. It has not yet been proven in ALS research. However, we know that all cells release glutamate when they die and that excess extracellular glutamate kills neighboring cells, regardless of the disease/condition.)
Dr. Tedone, Winning the Fight’s Medical Liaison, hypothesizes that somehow, the exposure to excess extracellular glutamate in ALS kills neighboring healthy neurons by interrupting the Krebs Cycle in each of them. Dr. Tedone’s hypothesis holds that this Krebs Cycle interruption is a chief cause of cell death. After all, when cells cannot produce energy efficiently, they die.
How the Deanna Protocol® Metabolic Plan Helps Stop Cell Death Caused by Extracellular Glutamate in ALS
Does the Deanna Protocol® Metabolic Plan (DP™ Plan) neutralize the excess extracellular glutamate in ALS? No. The DP™ Plan focuses on cell metabolism. The DP™ Plan delivers Alpha-ketoglutarate (AKG) to the Krebs Cycle in the neurons. The increase in AKG enables their mitochondria to produce enough energy to help keep cells alive, despite their exposure to an unhealthy amount of extracellular glutamate. AKG usually does not pass through the cell membranes in normal healthy cells. Based on the research of Winning the Fight and Dr. Tedone, they found that the permeability of the cell membrane in diseased or damaged cells changes and allows AKG to permeate the cells. Due to the fact that AKG only enters diseased cells, the substance only goes where it is needed.
Deanna Protocol® (DP™ Plan Essentials ) versus the Winning the Fight Program for ALS
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The Winning the Fight Program for ALS consists of a few different components. The overall program is separated into substances that have shown (in lab studies) to be effective in ALS and substances that promote overall neuromuscular health. The first and most important component of the Winning the Fight Program for ALS is the DP™ Plan Essentials. These substances are AAKG, AKG, GABA, Ubiquinol (CoQ10), Niacin (non-flush), and 5HTP (5-hydroxtrytophane).
Another component of the Winning the Fight Program for ALS consists of ancillary substances, some of which have been found effective in Deanna, but have not yet been proven in a lab, and others of which the National Institutes of Health (NIH) claims maintain the health of the nervous system and muscles. Many of these ancillary substances can be supplied by a healthy diet. However, individuals with ALS may need more of them than healthy individuals, which is why taking the ancillary substances makes sense for those who can afford to cover the cost. The NIH has published a manuscript "Nutrition and Supplements in Motor Neuron Diseases" which emphasizes the importance of nutrition to support quality of life for PALS.
Simplesa products include all the ingredients contained in the DP™ Plan Essentials, as well as the ancillary substance Liposomal Glutathione (found effective in Deanna), and the rest of the ancillary supplements (contained in AM and PM blends). The following Simplesa products make it easy to follow these nutritional regimens:
Deanna Protocol® DP™ Plan Essentials: Necessary Supplements
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- AAKG+ Core Powder contains the full recommended daily dosages of GABA, Ubiquinol and Niacin and the minimum dose of AAKG.
- AAKG Powder, used to increase your AAKG level at your own pace to your own maximum level
- 5HTP Capsules
- AKG, available as liquid or capsules
Ancillary Supplements: For Extra Benefit
- Liposomal Glutathione Liquid
- Total Health AM & PM, available as powders, contain an additional 20 nutrients to support nerve and muscle health based on research from the National Institutes for Health
Please call (888) 578-5528 with any questions or CLICK HERE to read our FAQs
CORE BUNDLES
All DP™ Plan Essentials nutrients
PLUS BUNDLES
All DP™ Plan Essentials nutrients
+
Liposomal Glutathione
Liposomal Glutathione is considered the best antioxidant for the central nervous system.
COMPREHENSIVE BUNDLES
All DP™ Plan Essentials nutrients
+
Liposomal Glutathione
+
Total Health AM & PM
The Total Health AM & PM contain 20 nutrients that support muscle and nerve health based on research from the NIH. All are included in the Winning the Fight Program for ALS.
FOLLOWING THE DEANNA PROTOCOL IS EASY:
For patients with Amyotrophic Lateral Sclerosis (ALS) following the Deanna Protocol, Simplesa offers products to simplify this routine and build on this regimen.

MORNING
Add one scoop of Simplesa AAKG+ Core Powder** and, if adding, 1 scoop of Simplesa Total Health AM & PM to 4 to 8 ounces of water or other liquid and drink. Take 1 teaspoon of Liposomal Glutathione.

AFTERNOON
Add 1 scoop of Simplesa AAKG+ Core Powder** to 4 to 8 ounces of water or other liquid and drink.

EVENING
Add one scoop of Simplesa AAKG+ Core Powder** and, if adding, 1 scoop of Simplesa Total Health AM & PM to 4 to 8 ounces of water or other liquid and drink. Take 1 capsule of 5-HTP.

Throughout the Day
Each waking hour between doses of the Simplesa AAKG+ Core Powder, add one dropper of Simplesa AKG Liquid to 4 to 8 ounces of water or other liquid and drink, or take 1 capsule of Simplesa AKG+.

**Simplesa AAKG+ Core Powder is formulated to provide 9gm of AAKG/day. Supplementation with additional AAKG may be needed depending on your requirements.
Winning the Fight, Inc.
Winning the Fight, Inc. The Deanna Protocol is overseen by the 501(c)3 nonprofit Winning the Fight, Inc. (WFND). WFND is a 100% volunteer organization with a home base in Tampa, FL, and a network of volunteers and donors around the world. They are dedicated to raising awareness about neurodegenerative diseases (NDs), as well as seeking and funding new treatments for NDs.
WFND strives to slow the progression of these diseases to extend the lives of those affected and enhance quality of life until a cure is found. They raise funds by hosting events, internet campaigning, and also by submitting grant proposals to a variety of prospective corporate and non-profit donors. Donations to Winning the Fight, Inc. may be tax deductible to the fullest extent allowed by law. Please mail your donation to
Winning the Fight, Inc., 11706 N. Armenia Ave. Tampa, FL 33612
or