The Simplesa® Neuro-Health Protocol *

A natural supplement program for those experiencing ALS and other Neurodegenerative and Motor Neuron (MND) Concerns

The Simplesa® Neuro-Health Protocol for Neurodegenerative concerns is part of a comprehensive and all-natural supplement program designed to help improve the nutritional support for those suffering from Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease), Parkinson’s disease and other Neurodegenerative and Motor Neuron concerns. The supplements in the Neuro-Health Protocols include those indicated to be effective by other known protocols for ALS and includes a combination AAKG, GABA, CoQ-10, Niacin, 5-HTP and others. In addition, Simplesa has created its own unique proprietary blends that are exclusively available in the Simplesa Neuro-Health Protocols.*

The Neuro-Health Protocol may also be beneficial for other neurodegenerative and motor neuron concerns such as: Primary Lateral Sclerosis (PLS), Progressive Muscular Atrophy (PMA), Kennedy’s Disease, Dystonia, and others.

The Neuro-Health Protocol combines all the nutrients for positive neuro-nutritional support into 3 easy-to-use product groups or Bundles that are also very easy to order. These 3 groups are the Core Bundle, the Plus Bundle and the Comprehensive Bundle. Each Bundle, starting with the Core, then Plus and then the Comprehensive Bundle, provide increasing levels of nutritional support.

For those having difficulty swallowing, we replace the AKG+ Capsules with AKG Liquid, which is easier to swallow. We give these bundles that use the AKG Liquid the designation of Bundles “#2”. Either bundle designation #1 or #2 is equally effective.

All Bundles precisely match the Neuro-Health Protocol dosages and required nutrients and provide a complete, 30-day supply of all necessary supplements in the Protocol.

In addition, each Bundle provides complete, step-by-step instructions, Free Shaker Bottle, online videos, and a personalized customer service representative ready to answer any questions.

Why the Simplesa ® Neuro-Health Protocol Works
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Glutamate, ALS, and Cell Death

To understand the basis for the Neuro-Health Protocol, one must first consider the pathology in neurodegenerative conditions in general and ALS specifically. One theory says that death of motor neurons spreads throughout the body in individuals with ALS due to glutamate. When cells die, they burst and release intracellular glutamate into the extracellular space. This increase in extracellular glutamate causes neighboring healthy motor neurons to die, to burst, and to release more glutamate into extracellular space, which will kill even more neighboring cells. This so-called storm of glutamate in ALS causes cell death to happen at an exponential rate. (The spread of cell death via excess extracellular glutamate has already been proven in other neurodegenerative conditions, such as traumatic brain injury. It has not yet been proven in ALS research. However, we know that all cells release glutamate when they die and that excess extracellular glutamate kills neighboring cells, regardless of the disease/condition.)

The same theory, hypothesizes that somehow, the exposure to excess extracellular glutamate in ALS kills neighboring healthy neurons by interrupting the Krebs Cycle in each of them. The Krebs Cycle interruption is possibly a chief cause of cell death. After all, when cells cannot produce energy efficiently, they die.

How the Neuro-Health Protocol by Simplesa ® May Help Stop Cell Death Caused by Extracellular Glutamate in ALS

Does the Neuro-Health Protocol neutralize the excess extracellular glutamate in ALS? No. The Neuro-Health Protocol focuses on cell metabolism. The Neuro-Health Protocol delivers Alpha-ketoglutarate (AKG) to the Krebs Cycle in the neurons. The increase in AKG enables their mitochondria to produce enough energy to help keep cells alive, despite their exposure to an unhealthy amount of extracellular glutamate.*

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Neuro-Health Protocol Essentials: Necessary Supplements
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  1. AAKG+ Core Powder contains the full recommended daily dosages of GABA, Ubiquinol and Niacin and the minimum dose of AAKG.
  2. AAKG Powder, used to increase your AAKG level at your own pace to your own maximum level
  3. 5HTP Capsules
  4. AKG, available as liquid or capsules

Additional Supplements: For Extra Benefit*

  1. Liposomal Glutathione Liquid
  2. Total Health AM & Total Health PM, available as powders, contain an additional 20 nutrients to support nerve and muscle health based on research from the National Institutes for Health.

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Please call (888) 578-5528 with any questions or CLICK HERE to read our FAQs


Add one scoop of Simplesa AAKG+ Core Powder** and, if adding, 1 scoop of Simplesa Total Health AM to 4 to 8 ounces of water or other liquid and drink. Take 1 teaspoon of Liposomal Glutathione.


Add 1 scoop of Simplesa AAKG+ Core Powder** to 4 to 8 ounces of water or other liquid and drink.


Add one scoop of Simplesa AAKG+ Core Powder** and, if adding, 1 scoop of Simplesa Total Health PM to 4 to 8 ounces of water or other liquid and drink. Take 1 capsule of 5-HTP.

Throughout the Day

Each waking hour between doses of the Simplesa AAKG+ Core Powder, add one dropper of Simplesa AKG Liquid to 4 to 8 ounces of water or other liquid and drink, or take 1 capsule of Simplesa AKG+.


**Simplesa AAKG+ Core Powder is formulated to provide 9gm of AAKG/day. Supplementation with additional AAKG may be needed depending on your requirements.

Warning: Please consult with your physician before starting with this or any other nutritional supplement program or if you are taking any medications, have any medical condition and before modifying your diet or using any new products. Do not use these products if you are pregnant or lactating. Keep out of the reach of children.

*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.